OIP — The Opportunity Intelligence PlatformOIP / Government Intelligence
Preparing the stored Government Intelligence discovery view.
OIP / Government Intelligence / Opportunity detail
Source: Stored live-derived Government dataNational Institutes of Health
OIP derived this review page from stored live-derived Government Intelligence source records. The official source and issuing agency remain authoritative.
Opportunity Intelligence Platform is an independent service and is not affiliated with or endorsed by the U.S. Government. Official notices, amendments, attachments, eligibility requirements, funding terms, and deadlines remain under source control.
OIP scores and explanations are informational and do not guarantee eligibility, suitability, compliance, contract award, or financial outcome.
No funding amount is disclosed in the stored source fields.
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Private institutions of higher education; City or township governments; Small businesses; Public and State controlled institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; State governments; County governments
2 warning(s) require review.
Objective score, derived by OIP
Publication decision: Publish with warning
Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed) -- a Grant (Grant) issued by National Institutes of Health.
Objective Government score 67 for grants-gov-357014, computed from source evidence and Government scoring configuration.
potential_value (not_applicable): potential_value is structurally not applicable for this Government category.
10 evidence record(s) support this pipeline result.
Next action: Review the official Grants.gov opportunity and follow the listed application package instructions.
95/100 · Ok
evidence_quality scored from source evidence and Government scoring guidance (value kind deterministic_calculation, confidence rank 0).
90/100 · Ok
confidence scored from source evidence and Government scoring guidance (value kind rule_based_evaluation, confidence rank 1).
No numeric value · Not Applicable
potential_value is structurally not applicable for this Government category.
62/100 · Ok
urgency scored from source evidence and Government scoring guidance (value kind deterministic_calculation, confidence rank 0).
56/100 · Ok
difficulty scored from source evidence and Government scoring guidance (value kind rule_based_evaluation, confidence rank 1).
62/100 · Ok
time_required scored from source evidence and Government scoring guidance (value kind rule_based_evaluation, confidence rank 1).
48/100 · Ok
capital_required scored from source evidence and Government scoring guidance (value kind rule_based_evaluation, confidence rank 1).
52/100 · Ok
risk scored from source evidence and Government scoring guidance (value kind rule_based_evaluation, confidence rank 1).
68/100 · Ok
novelty scored from source evidence and Government scoring guidance (value kind rule_based_evaluation, confidence rank 1).
Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)
$.detail.opportunityTitle · Field Mapping · 98/100 confidence
357014 / PAR-25-153
$.detail.id · Field Mapping · 99/100 confidence
National Institutes of Health
$.detail.synopsis.agencyName · Field Mapping · 97/100 confidence
Grant
$.detail.synopsis.fundingInstruments · Field Mapping · 96/100 confidence
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.
$.detail.synopsis.synopsisDesc · Field Mapping · 94/100 confidence
2024-11-06T05:00:00.000Z
$.detail.synopsis.postingDate · Field Mapping · 96/100 confidence
2026-09-07T00:00:00.000Z
$.searchHit.closeDate · Field Mapping · 92/100 confidence
Official source materials control eligibility, deadlines, amendments, attachments, and funding terms.
Open official sourceApplicant types: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Private institutions of higher education; City or township governments; Small businesses; Public and State controlled institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; State governments; County governments
$.detail.synopsis.applicantTypes · Field Mapping · 94/100 confidence
value_not_disclosed
$.detail.synopsis · Field Mapping · 84/100 confidence
2024-11-06T18:05:14.000Z
$.detail.synopsis.lastUpdatedDate · Field Mapping · 88/100 confidence